Non-Invasive Prenatal Screening (NIPT) near Senawang, Seremban

Peace of Mind, One Genetic Insight at a Time: NIPT and NICC Tests at Klinik Casabrina

At Klinik Casabrina, we understand that pregnancy can be an exciting and sometimes anxious time for expectant parents. That’s why we’re dedicated to providing advanced prenatal care options to ensure the health and well-being of both mother and baby.

We offer two options for prenatal screenings as part of our antenatal care: Non-Invasive Prenatal Testing (NIPT) and Non-Invasive Chromosomal Copy Number Variation (NICC). Both are advanced screening methods that offer valuable insights into the genetic health of the fetus with a simple blood test.

Sakit Puan Klinik Casabrina Senawang
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What is NIPT and NICC?

NIPT, or Non-Invasive Prenatal Testing, is a cutting-edge screening test that examines the fetal DNA present in the mother’s blood. This test can detect the risk of certain chromosomal abnormalities, such as Down syndrome (Trisomy 21), Edwards syndrome (Trisomy 18), and Patau syndrome (Trisomy 13), as well as abnormalities in the number of sex chromosomes (such as Turner syndrome or Klinefelter syndrome).

NICC, or Non-Invasive Chromosome Check, is a much newer and  less established prenatal screening option similar to NIPT. It’s a blood test that specifically targets chromosomal copy number variations (CNVs) and microdeletion syndromes. Unlike NIPT, NICC is designed to detect a broader range of genetic abnormalities. It analyses cell-free fetal DNA in the maternal bloodstream to identify deletions, duplications, or other structural variations in specific chromosomal regions associated with genetic disorders.

How Does NIPT Work?

Both tests do this by measuring the amount of cell-free fetal DNA (cffDNA) in the mother’s blood, which enters the bloodstream from the placenta during pregnancy. NIPT utilises this fetal DNA to analyse specific chromosomal regions for any abnormalities. This is a non-invasive procedure, meaning it carries no risk to the fetus or mother. A simple blood sample from the mother is all that’s needed to conduct the test.

Why Choose Non-Invasive Prenatal Tests?

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Accuracy

NIPT boasts high levels of accuracy in detecting common chromosomal abnormalities, with a low rate of false positives.

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Safety

Unlike traditional invasive prenatal tests, like chorionic villus sampling (CVS), NIPT does not pose any risk of miscarriage or harm to the fetus.

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Early Detection

NIPT can be performed as early as 9-10 weeks into the pregnancy, providing expectant parents with timely information about their baby's health.

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Peace of Mind

Knowing whether your baby is at risk for certain genetic conditions can offer reassurance and help parents prepare for any necessary medical or support services.

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It’s important to note that while NIPT and NICC are highly accurate screening tests, they are not diagnostic tests. Positive results should be confirmed with further diagnostic testing, such as amniocentesis or chorionic villus sampling (CVS), to provide a definitive diagnosis. Additionally, NIPT and NICC may not be suitable for all pregnancies, so it’s essential to discuss the options with your doctor here at Klinik Casabrina Senawang to determine the most appropriate screening strategy based on individual circumstances and preferences.

Who Should Consider NIPT?

NIPT tests and NICC tests are recommended for pregnant women who fall into one or more of the following categories:

Women of Advanced Maternal Age: Pregnant individuals who are 35 years old or older have a higher risk of having a baby with chromosomal abnormalities such as Down syndrome (Trisomy 21), making them potential candidates for NIPT and NICC.

Women with Positive Screening Results: Pregnant individuals who have received positive results from other prenatal screening tests, such as first-trimester combined screening or maternal serum screening, may opt for NIPT or NICC to obtain further information and clarify their risk.

Women with a Previous Pregnancy Affected by Chromosomal Abnormalities: Pregnant individuals who have previously had a pregnancy affected by chromosomal abnormalities may choose NIPT or NICC for early detection and planning in subsequent pregnancies.

Known Genetic Conditions or Family History: Pregnant individuals with known genetic conditions or a family history of chromosomal abnormalities may consider NIPT or NICC for additional reassurance and planning.

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Testimonials

Our Happy Customers Reviews

Good services provided by the staff and doctor Shabrina. The first time I came as a patient, but I've been to this clinic 3 times, bringing other people who were sick. Thanks doc for the advice and consultation.
Ellne AteaEllne Atea
03:09 03 Mar 24
Jannanee NaiduJannanee Naidu
02:31 03 Mar 24
Adnan YahoAdnan Yaho
11:07 02 Mar 24
the best service like anywhere else...try it guys
yuliani osmanyuliani osman
10:43 02 Mar 24
Friendly staff.. The ambiance is also very attractive
nea sayangnea sayang
05:07 17 Feb 24
im a single mother and to be mommy soon , its so nice to have such an understanding doctor and very professional they respect your situation and very kind :)) the clinic very comfy and so private you can feel you just made a check up at home 🥹❤️
Muzdalifah Mustafa -Muzdalifah Mustafa -
10:30 27 Dec 23
Cozy clinik, friendly asisstant and nice doctor.. toilet very clean!!!
Bella AzmiBella Azmi
07:28 26 Dec 23
I been here for ovarian cyst problem, lead and advice by great Dr Sabrina. Love the condition of the clinic and helpful staff. Recommend!!
fara rahimfara rahim
06:28 08 Dec 23
Great service, even my first time here. Suggested by a friend. Very cosy, clean and spacious clinic. Thank you for your asistant. Doc & staff very friendly. Cannot wait for next appointment 😊
Cap HafizCap Hafiz
01:58 18 Sep 23
Thank you, Dr. Shabrina and team. I had a great experience here. The price is very affordable for a great consultation and a referral letter.She is very attentive and checked my eyes thoroughly, and I feel so satisfied with her explanation regarding my eye condition. The clinic is spacious, clean, and not crowded either. Overall, excellent and pleasant experience. 👍🏻
Adnan AbbasAdnan Abbas
12:10 25 Aug 23
At first, I really wanted to go to this clinic because I was new..but then I tried to walk in..just entered the clinic..it was really comfortable..and it didn't look crowded..simple and just nice..and when I brought my wife in for a scan pregnant..the system looks sophisticated..the doctor and staff are friendly..xsmong..highly recommend this clinic..
Nur Farah NabilahNur Farah Nabilah
10:47 04 Aug 23
very comfortable clinic. the explanation from the doctor was also very detailed when going for a scan. the doc is also very friendly and makes us comfortable & explains very detailed, especially for first moms who don't have much knowledge 😍 btw really recommended + affordable price !!!
Zulaikha Anis FadilZulaikha Anis Fadil
08:52 02 Jul 23
Gonna be my fav clinic! Really recommended, family friendly. There is a reading room, play room, doctor Sabrina & Shira's staff are also friendly. Explanation Dr is very clear. Hopefully my baby Hannah Dahlia will be given good health and recovery ❤️
Dila BorhanDila Borhan
08:52 28 Jun 23
Alhamdulillah happy business and Dr. as well as the staff from the clinic are also very friendly and intimate...love it 🥰🫰🏻Thank You...
Siti FatimaSiti Fatima
03:43 17 Jun 23
Very good service and really friendly clinic assistant & doctor staff. Highly recommended for upt tests or baby scans! 🥰 Monthly pn mur mur.
Dr HananDr Hanan
07:33 19 May 23
visited this clinic as a patient (they didn't know i'm a health professional too). the resident is really well knowledge, good attitude, explained to me about the illnesses and treatment, friendly. their medications are top tier with affordable consultation fee compared to other clinic. the clinic is spacious, comfortable and kids friendly. i see they offer lots of other services such as antenatal check up (female doctor), medical check up and other laboratory services. highly recommended.
fadhzillah ashraffadhzillah ashraf
08:17 30 Apr 23
Nice clinic! Doctor sabrina is a very nice doctor.. she gave jab to my daughter and explained everything in details to me and husband.. she examined our daughter so friendly! Price also very affordable, and will recommend my friends to come here
Fast and professional service from the staff. Doctor was very gentle for my influenza test. Will come back again for the influenza shot 🤩👍🏻
Nur ABNur AB
01:40 21 Apr 23
Recommended! Dr Shabrina is great. She has been very attentive to my health issues and explain everything in details. Will come again to this clinic.
LeiyanahLeiyanah
00:14 21 Apr 23
New clinic in town. Big spacious clinic, friendly staff and very professional service by Dr Shabrina. Get your local Dr's consult from this clinic. Recommended !
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What to Expect During NIPT

Counselling

Before undergoing NIPT, expectant parents will typically receive genetic counselling to discuss the test’s purpose, benefits, and limitations.

Blood Draw

A small blood sample will be collected from the mother’s arm using a standard venipuncture procedure. This process is quick and relatively painless.

Laboratory Analysis

The blood sample will be sent to our expert lab, where highly trained technicians will extract and analyse the fetal DNA.

Results

Results are usually available within 7-10 days. A healthcare provider will discuss the findings with parents and provide appropriate guidance.

Understanding NIPT results

Common Diseases Sensitivity¹ Specificity² PPV (Positive Predictive Value)
Down syndrome 99% 99% 80-95%
Edwards syndrome 98% 99% 70-85%
Patau syndrome 99% 99% 50-80%
Sex chromosome abnormalities 95-99% 99% 80-95%

¹Sensitivity refers to the ability of the NIPT test to correctly identify individuals who have the condition (true positive rate). It indicates the percentage of affected pregnancies that are correctly identified as positive by the NIPT. Higher sensitivity values indicate better performance in detecting the condition when it is present.

²Specificity refers to the ability of the NIPT test to correctly identify individuals who do not have the condition (true negative rate). It indicates the percentage of unaffected pregnancies that are correctly identified as negative by the NIPT. Higher specificity values indicate better performance in correctly ruling out the condition when it is not present.

Commonly Detected Diseases

A genetic disorder caused by the presence of an extra copy of chromosome 21, resulting in developmental delays, intellectual disability, and distinct physical features such as slanted eyes and a flattened face.

Also known as Trisomy 18, it is a chromosomal disorder caused by an extra copy of chromosome 18. Individuals with Edwards syndrome often have severe developmental delays, heart defects, and characteristic physical abnormalities such as clenched fists and overlapping fingers.

Also known as Trisomy 13, it is a chromosomal disorder caused by an extra copy of chromosome 13. Patau syndrome is characterised by severe intellectual disability, heart defects, and physical abnormalities such as cleft lip and palate, extra fingers or toes, and brain abnormalities.

A genetic condition in males caused by the presence of an extra X chromosome, resulting in infertility, underdeveloped testes, and may lead to reduced muscle mass, tall stature, and learning disabilities.

A genetic condition in females characterised by the presence of an extra X chromosome, resulting in variable symptoms such as tall stature, learning disabilities, delayed development, and may increase the risk of certain health conditions such as autoimmune disorders and behavioural issues.

Please note that the values provided for sensitivity, specificity, and PPV are approximate ranges and may vary slightly depending on the specific test used and the population being studied. Additionally, PPV can vary based on factors such as maternal age and prevalence of the condition in the population. Always consult with a healthcare professional for the most accurate and up-to-date information regarding prenatal screening tests.

Antenatal Clinic Casabrina Senawang

Why Choose Us For Your Parenthood Journey?

  • Expertise in Reproductive Health: We specialise in reproductive health, bringing together a team of experienced and compassionate healthcare professionals dedicated to guiding you through your fertility journey.
  • Privacy and Comfort: We prioritise your comfort and privacy during all “Sakit Puan” care services.
  • Proactive Family Planning: Our focus is on proactive family planning. Whether you are just starting your family or addressing specific concerns, we are committed to help you to achieve family goals.

Book An Appointment

Scheduling an appointment for your antenatal checkup is easy. Contact our friendly staff via phone or email to book your consultation. We strive to accommodate your schedule and ensure timely care.

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Call Us

Doctor's appointment

icon email

Email Us

klinikcasabrina@gmail.com

Monday to Sunday
09.00 am - 09.00 pm